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Novo Nordisk signs deal for monthly GLP-1 agonist Novo Nordisk is putting down up to US$362m to tap into Ascendis TransCon technology for treatments in metabolic and cardiovascular diseases
Importantly, the receptor for GLP-1 (GLP-1R) is abundantly expressed by vagal afferents 12,26,27 and physiological studies indicate that peripheral nerves are, at least in part, necessary for both endogenous GLP-1 and administered GLP-1 receptor agonists satiating and incretin effects 12,28,29,30,31,32
Experts say patients taking GLP-1-based medications should monitor for mood changes and report symptoms such as: New or worsening depression Anxiety or emotional changes Suicidal thoughts More research is needed to determine whether these drugs directly affect mood or whether changes are related to factors such as rapid weight loss, hormonal changes or other metabolic effects
A liquid is already broken down - it contacts the absorption surface faster and with less degradation in the process