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If someone has a serious B12 shortage, it might take several doses to feel energized again
The increase in vitamin B12 levels in non-responders was significant but much lower than the increase in levels among the responders
SAM is an all-purpose methyl group donor that participates as a co-factor in a variety of physiological and cellular processes, including lipid homeostasis
Vitamin B12 Methylcobalamin tablets form is the most bioactive and bioavailable form which means it is the most readily absorbed by the body giving 5X better results than any other form
Given that, the sensible position is to treat the drug-interaction contraindications as firm, particularly antidepressants and stimulants, while accepting that for someone on no such medications the risk is likely small but genuinely unquantified
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