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Peer review Peer review information Nature Aging thanks Yeijing Ge and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
Zepbound (tirzepatide) is the same medication as Mounjaro under a different name, approved in Japan specifically for obesity treatment as of April 2025
These receptors regulate pigmentation signaling pathways responsible for eumelanin synthesis
The selective inhibitor compound 27 (IPN60090), which is currently in a first-in-class clinical trial, focuses on optimising physicochemical and pharmacokinetic properties, with a strong in vivo target engagement capability, and should strongly inhibit GLS in humans [152, 153]
1 Introduction According to the latest iteration of the definition, sepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infection (1)
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