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With the oxygen free radicals or nonradical species attack, PUFAs will be oxidized to lipid peroxyl radicals and hydroperoxides, eventually lead to the cell membranes damage and cell death [16,17,18]

Another autophagy inhibitor 3-MA also produced rescuing effects but to a smaller extent in erastin-treated cells

It also plays a role in converting homocysteine, an amino acid, into methionine, thereby helping to maintain healthy homocysteine levels

On the contrary, microsomal GSTs, also known as MAPEG (membrane-associated proteins involved in eicosanoid and glutathione metabolism), are integral membrane proteins which are not evolutionary related to the other major classes

Oxidative Medicine and Cellular Longevity, 2013