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Even when considered individually, investigational and unregulated peptides carry meaningful risks
Glutathione is a tripeptide (containing 3 amino acids: cysteine, glutamic acid, and glycine) naturally made in human cells that functions as a powerful antioxidant
Furthermore, increased ACE2 expression in alveolar type II pneumocytes and alveolar macrophages of individuals with severe SARS-CoV-2 disease (ARDS with diffuse alveolar damage) requiring mechanical ventilation (Baker et al., 2021) favors a concomitant increase in oxidative stress in those individuals
Women who describe persistent fatigue and a sense that their metabolism has slowed, often despite normal labs and adequate sleep, are sometimes candidates for MOTS-c as part of a broader metabolic protocol
