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Compared to M2-type macrophages, M1-type macrophages exhibit elevated expression of hepcidin antimicrobial peptide (Hamp), ferritin heavy chain (FTH), and ferritin light chain (FTL), with reduced levels of FPN and iron regulatory proteins 1/2 (IRP1/2), demonstrating enhanced iron storage capacity (96)
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Conversely, the administration of dynasore, an inhibitor of VEGFR2, failed to activate the pathway and inhibited endothelial tube formation [9]
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