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By conducting RNA-seq analysis, SOD activity and malondialdehyde assays in ovaries, as well as ROS staining in oocytes, we revealed that the semaglutide treatment reduced the elevated oxidative stress in ovaries and high ROS levels in oocytes from PPO mice, possibly through activating the PI3K/AKT pathway and improving the state of SOD
Why combination research differs from single-compound studies Combination studies require a different research design than single-compound studies, since researchers need to account for potential interactions between two active mechanisms rather than measuring a single variable in isolation
Finally, we detected apoptosis, proliferation, and migration in various treatment groups
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