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Lira (GLP-1R) can reduce the occurrence of hepatic steatosis in vivo and in vitro by enhancing autophagy and lipid degradation through the GLP-1R-transcription factor EB (TFEB)-mediated autophagy lysosomal pathway [37]
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Many patients remain asymptomatic until advanced disease develops, making incidental diagnosis through imaging or elevated liver enzymes common during routine health assessments
TMAO causes vascular dysfunction and hypertension, two important risk factors for ischemic stroke [77]
Remaining at a lower dose longer GLP-1 medications are typically started at a low dose and increased gradually to improve tolerability
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