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In addition to NO synthesis, l-Arg can also be catalyzed by arginine decarboxylase to produce agmatine [117], which improves EC function by enhancing eNOS activity, reducing mitochondrial ROS levels, and alleviating lipid accumulation through the AMPK/phosphatidylinositol 3-kinase (PI3K)/Akt/eNOS signaling pathway [125, 126]
MOTS-C rarely causes side effects
These processes are central to tissue regeneration
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