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The most common electrolyte imbalances associated with GLP-1 therapy are hypokalemia (low potassium), hyponatremia (low sodium), and hypomagnesemia (low magnesium), typically resulting from gastrointestinal losses through vomiting or diarrhea combined with reduced oral intake

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Central GLP-1R activation in hypothalamic and mesolimbic pathways may lead to fatigue, lethargy, or brain fog 63 , though such effects might be often transient and dose-dependent