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10.1128/AEM.00509-12

First, most of the milder effects fluid retention, a puffy feeling, minor joint stiffness cluster in the activation phase as the axis wakes up, and in the research framing they commonly settle as the body adapts

Nature 486(7402):207214 Zeng MY, Inohara N, Nuez G (2017) Mechanisms of inflammation-driven bacterial dysbiosis in the gut

While there seems to be supportive evidence stating the benefits of glutathione in reducing dark spots and even preventing new ones from forming, more research is still needed

These side effects are generally mild and temporary, but it is important to consult with a healthcare professional if any concerns arise.