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Glucarpidase (Voraxaze), a bacterial enzyme that cleaves methotrexate to form inactive metabolites, was FDA approved in 2012 for the treatment of toxic methotrexate concentrations caused by impaired kidney clearance

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As ALD progresses to severe alcoholic hepatitis and cirrhosis, treatment guidelines recommend adding hormonal therapy to the early-stage treatments to prevent and halt the progression of cirrhosis

"Efficacy and Safety of Cagrilintide in Combination with Semaglutide in Adults with Obesity: The REDEFINE 1 Randomized Clinical Trial." Journal of the American Medical Association, 2024, 331(5): 385-397

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