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In an alcohol-instilled rat model, gastric, esophageal, and duodenal lesions develop alongside loss of left gastric artery vessel presentation

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When taken orally, they face two major obstacles: Stomach acid: Hydrochloric acid (pH 1.5-3.5) denatures peptide bonds, breaking the molecule into inactive fragments before it can be absorbed Digestive enzymes: Pepsin, trypsin, and chymotrypsin in the stomach and small intestine specifically target peptide bonds for cleavage

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