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Clinical trials are raising the bar Retatrutide ~24% weight loss (triple agonist) MariTide 1216% weight loss (GLP-1 + GIP antagonist) CagriSema up to 20% weight loss + ~2% HbA1c drop Orforglipron oral GLP-1, HbA1c 1.5%, weight 7.6% IcoSema weekly sema + once-weekly insulin Even more exciting
PMID 21429935
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Nausea: Nausea is the most common complaint among patients taking GLP-1 medications, and higher doses tend to make the nausea more pronounced
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