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Elevated superoxide can combine with NO, resulting in the formation of the peroxynitrite radical and the protein oxidative damage biomarker, 3-NT

This supports better muscle recovery and reduces the deep, aching pain that often accompanies even minimal physical activity in chronic illness

Some residual damage to the nervous system may remain in people who sought treatment late in the illness

Researchers suggest that the GHK sequence may occur endogenously, specifically being released by cells, including fibroblasts, macrophages, and lymphocytes, during damage, as a result of collagen breakdown

Quality of evidence: II-B, Strength of recommendation: 1 Panel level of agreement: In total agreement 87%, in partial agreement 13% CFF measurement has been shown to be useful in diagnosing MHE