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Weight Loss Efficacy: What the Trials Show The most reliable data comes from the manufacturers pivotal trials, which are large, randomized, placebo-controlled and FDA-reviewed

This drug activates GLP-1, GIP and glucagon receptors

Phase 2 trial data (published in the New England Journal of Medicine, 2023) have demonstrated significant weight loss and improvements in glycaemic markers, but the complete safety profile including the precise risk of low blood sugar continues to be characterised

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DPP-4 Inhibitors in Other Countries In parallel with this development, other DPP-4 inhibitors were developed in Japan and South Korea