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Intravenous metformin was found to be less glucose-lowering than oral administration (Stepensky et al., 2002)
There isnt much to it, but there doesnt have to be, because it combines the best traits of an excellent supplement a relatively low cost, transparent testing and safety measures, and a high-enough dose to make a difference in small-enough capsules to provide flexibility
NEJM 2023 Blood pressure treatment trialists' collaboration meta-analyses Ridker PM, et al
Individual results depend on adherence, diet, and genetics
Why More Frequent Dosing Isn't Recommended Injecting semaglutide more than once per week would create excessively high blood concentrations, potentially overwhelming your GLP-1 receptors and increasing side effects without additional benefit
