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Tregs take up lactate via MCT1 (encoded by Slc16a1), convert it to pyruvate for entry into the TCA, and generate phosphoenolpyruvate (PEP) via PEP carboxykinase (PEPCK), which feeds back to promote gluconeogenesis and nucleotide synthesis to support Treg proliferation
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It also regenerates vitamins C and E and plays a central role in hepatic detoxification through glutathione S-transferase conjugation reactions
Topical application works for this
doi: 10.1016/j.exger.2018.11.016 55 DaviesM
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