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Pernicious anemia occurs more commonly in people who already have diseases that are linked to immune-system abnormalities, such as Graves disease, hypothyroidism (under-functioning thyroid gland), thyroiditis (inflammation of the thyroid), vitiligo, and Addison's disease (adrenocortical insufficiency)

The peptide stimulates an increase in NAD+, a cellular metabolism cornerstone, activating the sirtuin-1 gene, often dubbed the longevity gene

In a 2021 study conducted by Maar et al., the importance of TB-500 in cardiac regeneration and repair was emphasized