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This distinction matters because patients who read "you have a 4-day window" sometimes assume that means they can dose anywhere within a 4-day range around their scheduled day
The SURMOUNT-1 trial showed that patients regain approximately 50% of lost weight within 12 months of discontinuing tirzepatide (Jastreboff et al., NEJM , 2022)
It is based on a peptide sequence originally derived from a protein fragment found in human gastric juice
doi:10.2337/dc19-0749 39
395(2): p
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