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Preclinical observations include: Reduction in pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-) in animal models Potential effects on immune cell function and inflammatory signalling cascades Possible protective effects in models of inflammatory disease However, there is currently no robust clinical evidence supporting the use of GLP-1 receptor agonists for rheumatoid arthritis specifically
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adults reported taking GLP-1RAs for weight loss, diabetes, or another chronic condition, according to a November 2025 KFF Health Track poll
Presented at the American Heart Association 2023 Scientific Sessions and simultaneously published in the NEJM , the double-blind, randomized, placebo-controlled, event-driven superiority trial enrolled 17,604 patients aged 45 years or older with a BMI of 27 kg/m2 or greater from more than 800 centers in 41 countries
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