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Javitt DC, Steinschneider M, Schroeder CE, Arezzo JC (1996)

Independent groups have observed consistent patterns across the published research record, providing cross-laboratory replication for the core mechanism findings documented in the foundational papers cited above

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As fibrosis progresses, tissue stiffening and local hypoxia further promote persistent epithelial injury and myofibroblast activation, creating a vicious cycle that drives disease progression [37]

Baseline Therapy Daily medications used to maintain mast cell stability and reduce flare frequency