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Northern communities and smaller towns may have less variety and higher prices during winter months

As with CYP2E1, there are substantial inter-ethnic differences in CYP2D6 across populations, ranging from complete loss of function or reduction in functional activity (2570% of the population, dependent on ethnic origin and geographical location) to extensive, ultra-rapid metabolisers (1.59.3% of the population) (see Table 3 in the supplementary data for a summary of the evidence) [17, 38]

doi: 10.1038/clpt.1981.92 21 Biozeus Biopharmaceutical SA (2018)

The same principle applies: recalculate and adjust

I., Bosboom, W