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Preclinical studies have demonstrated their ability to reduce drug-seeking behavior and substance intake, with promising results in alcohol, nicotine, and stimulant use disorders
In a Phase II trial for NASH, 59% of semaglutide-treated participants achieved NASH resolution compared to 17% on placebo, with no worsening of fibrosis
Reported EC50 values at this receptor vary by more than an order of magnitude across papers because of receptor expression level, cell background, incubation time, albumin content of the assay medium and the reference ligand chosen
That balance is what makes this review useful
Behav Ecol
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