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Effects of glucagon-like peptide-1 receptor agonists on major cardiovascular events in patients with type 2 diabetes mellitus with or without established cardiovascular disease: a meta-analysis of randomized controlled trials
Nature Medicine, 28(10), 20832091.
La principale differenza si riscontra nella loro struttura chimica e nelle loro funzioni biologiche
[27] on the antidiabetogenic effect of intestinal factors, and in 1929 by Zung & La Barre [28] on the release of a substance from intestinal mucosa with properties to decrease glycaemia, signalled the start of the development of the incretin concept and the study of the relationships between the gut and the endocrine pancreas
To be more specific, the GLP-1 receptor with an attached GLP-1 molecule had the function of instantly hydrolyzing glycosylphosphatidylinositols (GPIs), which generated short-lived inositolphosphoglycans (IPGs), and promoted phosphatidylinositol-3 kinase (PI3K) and mitogen-activated protein kinase (MAPK) activities (35)
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