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4.6
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McGowan agrees that exercise is essential and adds that resistance training is also beneficial, which the AHA suggests doing at least twice weekly

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HPA Axis and Stress Response Regulation Research has documented that oxytocin modulates the hypothalamic-pituitary-adrenal (HPA) axis, providing a mechanism for its observed anxiolytic properties[5]: Inhibition of corticotropin-releasing factor (CRF) release from the hypothalamus Attenuation of cortisol responses to psychosocial stressors in human studies Reduction of self-reported anxiety scores in both animal and human experimental paradigms Possible interaction with the autonomic nervous system to decrease heart rate reactivity Endogenous Oxytocin System Amplification A key unresolved mechanistic question is whether intranasal oxytocin acts directly at central OXTR or indirectly stimulates the release of endogenous oxytocin from hypothalamic neurons[6]

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