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Substrate binding in crystals In order to trap ligands in the active site, mature crystals were soaked overnight in 1 mM of either CuSO 4 or ZnCl 2 and subsequently in 10 mM of the appropriate ligand (KA and HQ) before crystal freezing

Exosomal miR-93 promotes proliferation and invasion in hepatocellular carcinoma by directly inhibiting TIMP2/TP53INP1/CDKN1A

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Most of the studies (7 out of 10) were conducted in China, and the remaining studies were performed in Europe (Sweden, Italy, and Germany, as described above)