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In addition, the characterized LASSS treatment did not stimulate autolysis of HGF as monitored by SDS-PAGE for degradation of 60-kDa -chain and 90-kDa proform of recombinant HGF incubated with LASSS (at 1:8000) at 25 for 2 h (see supplementary Figure 1b), providing another important basis for the availability of LASSS-HGF

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DeFranco EA, Valentine CJ, Carlson SE, Sands SA, Gajewski BJ (2024) Racial disparity in efficacy of docosahexaenoic acid supplementation for prevention of preterm birth: secondary analysis from a randomized, double-blind trial

Together, these three interventions create a coordinated assault on the fundamental mechanisms of aging: sermorelin restores the hormonal signaling environment, MOTS-c optimizes the cellular energy machinery, and NAD+ provides the molecular fuel that DNA repair and longevity pathways require to function