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In a pilot trial evaluating 104 amnestic MCI and early-stage AD patients, 20 IU and 40 IU doses of intranasal insulin improved Alzheimers Disease Assessment Scale-Cognitive subscale (ADAS-Cog 12) scores compared to placebo-treated patients, with improvements in delayed recall observed 2 months following cessation of treatment in the 20 IU group

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They act by binding to GLP-1 receptors, which are widely distributed in the body, including cardiomyocytes and blood vessels

Ji S, Yang H, Ji Y, Wu W, Dong Y, Fu H, Tang N, Hou Z, Wang F

Women of childbearing potential are encouraged to use contraception during therapy