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Because the complex carries copper, the relevant exposure question for any systemic route is the copper as much as the peptide
Published research describes 5-amino-1-methylquinolinium as a membrane-permeable small-molecule NNMT inhibitor used in preclinical and mechanistic studies
This makes it an ideal route for peptide delivery
Several clinical trials are currently underway
The enriched IGF-1/LR3 eluate is dried in a speed vac to remove TFA, and then reconstituted for subsequent reduction, alkylation, and tryptic digestion
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