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The Medicines and Healthcare products Regulatory Agency (MHRA) approved Mounjaro in the UK based on evidence from the SURPASS clinical trial programme

Some compounding pharmacies offer versions of oral tirzepatide, but these are not FDA-approved and lack comprehensive clinical evidence showing that oral tirzepatide works as effectively as its injectable counterpart

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192,193 For example, one research group used LNPs to deliver mRNA encoding erythropoietin into mouse fetuses, thus increasing erythropoietin protein levels in the mouse bloodstream

These findings highlight the potential for oral formulations to expand access beyond patients already receiving injectable therapies, according to the report