This dual action, enhancing inhibitory GABA while reducing excitatory NMDA, creates conditions favorable for transitioning into and maintaining sleep
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Acute peripheral neuropathy that usually occurs in a few hours after Pt drug administration is easily induced by the exposure to cold temperature, whereas chronic peripheral neuropathy tends to appear upon reaching a certain cumulative dose [e.g., OXA of 780 mg/m 2 (Rothenberg et al., 2003), CP of 350 mg/m 2 (Krarup-Hansen et al., 2007)] and can be characterized by sensory neurotoxicity (e.g., sensation loss and changes) due to the accumulation of Pt drugs at the peripheral nervous system (Cersosimo, 2005)
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