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For these reasons, peptides should always be used under the supervision of a qualified physician who can evaluate medical history, order appropriate labs, discuss realistic expectations, and monitor for benefits and adverse effects

Electrophysiological recordings support this notion and have demonstrated that GLP-1 directly stimulates POMC/CART cells, whereas GLP-1 can also inhibit orexigenic NPY/AgRP cells in the ARC through an indirect mechanism (Secher et al., 2014)

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Ideally, it's taken at the same time every day so it becomes routine