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Thus, in the TME, antitumor effects can be enhanced, and adverse effects such as immunosuppression and tumor metastasis can be reduced
This is not surprising since the insulin/IGF-1 pathway is able to control immune responses through a complex signaling network in a context-dependent manner including the activation of the NF-B system and mTOR signaling
Brain Dev (1999) 21(2):1137
insulin, a peptide hormone and drug used to treat diabetes
Evaluation of natural substances from Evolvulus alsinoides L
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