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Advertisement With this dual agonism, tirzepatide has demonstrated the largest weight loss in a randomized trial of any medication for obesity/overweight to date, with its highest dose achieving a 22.5% reduction relative to placebo at 72 weeks in the phase 3 SURMOUNT-1 trial ( N Engl J Med

In these trials, data on renal outcomes were also collected (Table 1), although not all trials had this as a prespecified outcome, and therefore the data should be interpreted with caution

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