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Current findings suggest that active components in herbal medicine (e.g., curcumin, resveratrol) activate the Nrf2 pathway by covalently modifying cysteine residues on Keap1 protein (Nosrati-Oskouie et al., 2022)

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Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy

Also, expanding regulatory approvals for obesity indications have reinforced this segments dominance