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A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
Kim S, Kang SW, Joo J, Han SH, Shin H, Nam BY, Park J, Yoo TH, Kim G, Lee P, et al
64,65 Tumors may also evade immune surveillance by downregulating tumor-associated antigens (TAAs), selecting for neoantigen-depleted clones, or upregulating alternative inhibitory checkpoints, as observed in EGFR-mutant non-small cell lung cancer (NSCLC) following targeted therapy
In this review, we specifically focus on the MTHFR polymorphism and related methylation and folate effects on psychiatric diseases as well as the possibility of relationship between clinical phenotypes of MTHFR-related diseases and effectiveness of clinical treatment in psychiatric patients 11
