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865 Induced pluripotent stem cells and organoid Recent advancements in generating patient-specific human iPSCs and their derived cells and organoids have established robust models for investigating the pathophysiological mechanisms of various mitochondrial genetic diseases, including MELAS, 866 MERRF, 283 Leigh syndrome, 795 Friedreichs ataxia, 867 and LHON 868 These iPSCs, along with their derived cells and organoids, address the challenges of sample acquisition while preserving patient-specific genetic backgrounds and accurately replicating disease characteristics

If these byproducts build up, they can damage the very mitochondria that created them

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