The enzyme CHAC1 (CHAC1/BOTCH for blocking NOTCH) is a key regulator of this process (Figure 6)
Research has examined DSIP's interactions with corticotropin-releasing hormone (CRH) and ACTH pathways, with investigators studying how the peptide influences stress hormone cascades in both in vitro and animal model systems
Vittone J, Blackman MR, Busby-Whitehead J, Tsiao C, Stewart KJ, Tobin J, Stevens T, Bellantoni MF, Rogers MA, Baumann G, Roth J, Harman SM, Spencer RG
BMC Complement Med Ther 26 , 195 (2026)
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