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Passive diffusion accounts for about 1% of total absorption, and this route of absorption is unaffected in patients with pernicious anemia ( There were studies in the 1950s and the1960s that showed that oral vitamin B12 could be absorbed by patients with pernicious anemia and could lead to resolution of the anemia ( The objective of our review is to inform clinicians on the effectiveness of oral vitamin B12 as adequate replacement in patients with pernicious anemia, as well as make recommendations on the dosing and frequency of clinical and laboratory monitoring

Schuetze SM, Wathen JK, Lucas DR, Choy E, Samuels BL, Staddon AP, et al

The 2023 absorption study cited above measured a 20+ fold increase in peptide delivery using this approach versus topical alone

Introducing Injectable NAD+ by Get Thin MD: The Ultimate Cellular Energy Booster for GLP-1 Users Our medical-grade NAD+ injection program delivers pure nicotinamide adenine dinucleotide directly to your system, providing immediate cellular energy and metabolic support: Targets fatigue at its source your cells' energy production centers Revitalizes metabolic function during caloric restriction Supports preservation of lean muscle mass Enhances mental clarity and cognitive function Works synergistically with your GLP-1 medication for optimal results Together, GLP-1 and NAD+ may have a synergistic effect

A similar outcome has been observed in C57BL/6 mice fed a HFD