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doi: 10.1016/S0140-6736(24)00469-0

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Crucially, ROS act as second messengers in seizure-associated neuroinflammation by activating the NF-B and activator protein-1 (AP-1) transcription factors, amplifying pro-inflammatory cytokine production such as IL-1 and TNF- through TLR4/MyD88 signaling [51]

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