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In a transgenic model of hair cell ablation in neonatal mice, Lgr5 -positive cells can, to a limited degree, proliferate and regenerate hair cells after damage (Cox et al., In addition to the mitogenic effect exerted by Wnt/-catenin signaling, studies on cochlear development in both mice and chicken suggest that overexpression of -catenin can induce ectopic hair cell formation (Stevens et al., 2003