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J Biol Chem 1992;267:7402-5.ArticlePubMed 16

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Breastfeeding: The American Academy of Family Physicians recommends waiting to take Benadryl until immediately after breastfeeding since its secreted in breast milk and can cause drowsiness and fussiness in babies

The most commonly reported side effects are gastrointestinal, including nausea, vomiting, and diarrhoea, consistent with the GLP-1 drug class