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Ice crystal formation physically destroys the peptide structure
Clinical trial data show nausea is common across GLP-1 therapies, regardless of routeranging from 11%20% with oral Rybelsus and up to 47% with oral Wegovy (25 mg), to 44% with injectable Wegovy and 12%18% with injectable Mounjaro
The early role of UPR is to reduce translation to lessen the need for new protein folding, degrade unfolded proteins to minimize damage, and increase the expression of chaperone proteins to assist protein folding
10.1038/ncomms14345 47 GarzaR
Kretzschmar, M., & Klinger, W
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