The threshold at which tirzepatide meaningfully reduces food intake rises as your body acclimates
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Following abrupt or tapered discontinuation in placebo-controlled clinical trials, the following symptoms occurred at 1% or greater and at a significantly higher rate in duloxetine-treated patients compared to those discontinuing from placebo: dizziness, headache, nausea, diarrhea, paresthesia, irritability, vomiting, insomnia, anxiety, hyperhidrosis, and fatigue
[2] [3] NICE guidance (NG28) recommends GLP-1 receptor agonists for adults with type 2 diabetes who have inadequate glycaemic control despite optimal management with metformin and other oral agents, particularly when significant weight loss would be beneficial