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(MP4 3429 kb) Studies investigating the mechanism of action of GLP-1RA therapy for causing weight loss provide evidence that GLP-1RA treatment is associated with reductions in appetite and hunger, lower preference for energy-dense foods, alteration in food reward pathways, decrease in food cravings, and improvement in eating control (Table 2) [25, 26, 33, 34]

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( c ) Mean response profile of bulk calcium fluorescence during a 10-minute bath application of semaglutide (100 nM) followed by 5-minutes of KCl (10 mM) from slices incubated in ACSF (black

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