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Originally developed for type 2 diabetes, clinicians quickly recognized their powerful impact on weight loss
Progressive NASH and fibrosis in GAN DIO-NASH-HCC mice was supported by quantitative histomorphometric analysis, indicating progressive increases in lipid accumulation (HE staining), inflammation (galectin-3), fibrogenic cell activity (-SMA) and collagen deposition (PSR staining, Col1a1) (Figs
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Eli Lilly markets them under different names for different FDA-approved indications, which affects insurance coverage, prescribing patterns, and patient access
In the pancreas, tirzepatide enhances glucose-dependent insulin secretion and reduces inappropriate glucagon release, which can improve glycemic measures
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