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Multiple bioactive compounds, including icariin, mangiferin, fraxin, poliumoside, picein, maresin-1, vitamin K2, and vitamin D analogs, promote osteogenic differentiation and suppress ferroptosis through activation of Nrf2/HO-1 signaling and restoration of Runx2-dependent programs (5557, 61, 62, 6874)

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TXNIP downregulates V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), a transcription factor to drive insulin expression, and thus negatively regulates insulin expression 25

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The "157" refers to the position of the 15-residue active fragment within a larger ~40-kDa protective protein originally isolated from human gastric juice