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Avoid strenuous exercise 24 hours before testing, as intense activity can temporarily affect certain blood markers

Semaglutide patients had more adverse events leading to permanent discontinuation of the study medication than did the placebo group, driven primarily by GI disorders

Per-meal threshold: Aim for at least 30-40 grams of protein per meal across 3-4 meals daily

When to seek urgent medical attention: Patients should seek prompt medical assessment if they experience severe or persistent abdominal pain (with or without vomiting), which may indicate pancreatitis or gallbladder disease, or if they develop signs of significant dehydration (dizziness, reduced urine output, rapid heart rate)

According to GRADE methodology, evidence for improvements in blood urea nitrogen, total cholesterol, and LDL-C was of moderate quality, whereas data on serum creatinine, UACR, fasting glucose, and HbA1c were rated low quality (248)