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PMID: 31408124, PMCID: PMC6692667, DOI: 10.1001/jama.2019.8594

Dozio E, Ruscica M, Passafaro L, Dogliotti G, Steffani L, Pagani A, Demartini G, Esposti D, Fraschini F, Magni P (2010) The natural antioxidant alpha-lipoic acid induces p27Kip1-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells

Moreover, RSL3 also behaved as a senolytic, selectively killing PC3 cells undergoing palbociclib-induced senescence (Fig

ICV injection of the dual GLP-1/GIP receptor agonist reduces the doses of GLP-1 and GIP, activates hypothalamic neurons (c-fos), and increases anorectic POMC gene expression, while treatment with the same dose of GLP-1 and GIP alone does not achieve these results

Peptides amplify adaptations but dont create them in a vacuum